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24 September 2025

Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial
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  • 640 (1)
    14 January 2026

    CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia

    N Engl J Med 2026: Landmark N Engl J Med study demonstrating CD19 CAR-T cell therapy as a novel curative approach for refractory autoimmune hemolytic anemia, achieving durable remission in patients who failed multiple lines of immunosuppression.
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  • 7b4ff45b-5a02-4d3c-b085-e2ea8409706c
    04 October 2025

    Donor-derived CD7 CAR-T Cells for Pediatric and Adult Relapsed/Refractory T-ALL/LBL

    Donor-derived CD7 CAR-T Cells for Pediatric and Adult Relapsed/Refractory T-ALL/LBL
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  • 091a8aae-8259-45f9-9384-31cf9efd2649
    17 April 2025

    Dasatinib and CAR T-Cell Therapy in Newly Diagnosed Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

    Dasatinib and CAR T-Cell Therapy in Newly Diagnosed Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
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  • 43a8d5c6-9ca2-438f-85b6-51855ea8bcfe
    19 May 2025

    BCMA/GPRC5D Bispecific CAR T-cell Therapy for R/R Multiple Myeloma with Extramedullary Disease

    J Hematol Oncol 2025: Phase 1 single-center trial demonstrating that BCMA/GPRC5D bispecific CAR-T achieves high response rates in multiple myeloma patients with extramedullary disease—a historically refractory population.
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  • 597e5a81-1b53-4cb0-8e93-86073a23ebea
    11 April 2025

    Anti-GPRC5D CAR T-cell Therapy as Salvage Treatment in Patients with Progressive Multiple Myeloma after Anti-BCMA CAR T-cell Therapy

    Lancet Haematol 2025: Phase 2 single-center trial confirming GPRC5D as an effective second target for anti-BCMA-progressed multiple myeloma, achieving meaningful responses in heavily pretreated patients.
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